Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity [chapter]
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Sasisekharan_Heparin and.pdf
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1.42 MB
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Author(s)
Shriver, Zachary H.
Capila, Ishan
Venkataraman, Ganesh
Sasisekharan, Ram
Date Issued
2012
Journal
Heparin - A Century of Progress
Publisher
Springer-Verlag Berlin Heidelberg
Citation
Shriver, Zachary, Ishan Capila, Ganesh Venkataraman, and Ram Sasisekharan. “Heparin and Heparan Sulfate: Analyzing Structure and Microheterogeneity.” Chapter in Heparin: a Century of Progress. Rebecca Lever, Barbara Mulloy, and Clive P. Page (Eds). Springer-Verlag Berlin Heidelberg (December 2, 2011): 159–176. (Handbook of Experimental Pharmacology; volume 207)
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Author's final manuscript
Abstract
The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their effects extracellularly by mediating key processes of cellular cross-talk and signaling leading to the modulation of a number of different biological activities including development, cell proliferation, and inflammation. This structural diversity is biosynthetically imprinted in a nontemplate-driven manner and may also be dynamically remodeled as cellular function changes. Understanding the structural information encoded in these molecules forms the basis for attempting to understand the complex biology they mediate. This chapter provides an overview of the origin of the structural microheterogeneity observed in heparin and heparan sulfate, and the orthogonal analytical methodologies that are required to help decipher this information.
Description
available in PMC 2013 August 28
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1007/978-3-642-23056-1_8
