DNA Damage and Its Links to Neurodegeneration
Name
nihms868500.pdf
Size
763.84 KB
Format
Adobe PDF
Checksum (MD5)
f055c5600c595a2e8754f3ec64053d00
Author(s)
Madabhushi, Ram
Pan, Ling
Tsai, Li-Huei
Date Issued
July 2014
Journal
Neuron
Publisher
Elsevier/Cell Press
Citation
Madabhushi, Ram et al. “DNA Damage and Its Links to Neurodegeneration.” Neuron 83, 2 (July 2014): 266–282 © 2014 Elsevier Inc
Version
Author's final manuscript
Abstract
The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system. We highlight the neuropathology of congenital syndromes that result from mutations in DNA repair factors and underscore the importance of the DNA damage response in neural development. In addition, we describe the findings of recent studies, which reveal that a robust DNA damage response is also intimately connected to aging and the manifestation of age-related neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis. Video Abstract: In this Review, Madabhushi etal. summarize the current state of knowledge about how DNA damage and changes to the DNA damage response in neurons might underlie neurodegenerative diseases.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.neuron.2014.06.034
