Triggerable tough hydrogels for gastric resident dosage forms
Name
Liu_et_al-2017-Nature_Communications.pdf
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1.7 MB
Format
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Checksum (MD5)
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Author(s)
Liu, Jinyao
Pang, Yan
Zhang, Shiyi
Cleveland, Cody
Yin, Xiaolei
Booth, Lucas
Lin, Jiaqi
Lee, Young-Ah
Mazdiyasni, Hormoz
Saxton, Sarah
Date Issued
July 2017
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Liu, Jinyao et al. “Triggerable Tough Hydrogels for Gastric Resident Dosage Forms.” Nature Communications 8, 1 (July 2017): 124 © 2017 The Author(s)
Version
Final published version
Abstract
Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ensure prolonged gastric residence, have the mechanical integrity to withstand the forces associated with gastrointestinal motility, be triggerable to address any side effects, and be drug loadable and release drug over a prolonged period of time. Materials that have been primarily utilized for these applications have been largely restricted to thermoplastics and thermosets. Here we describe a novel set of materials, triggerable tough hydrogels, meeting all these requirement, supported by evaluation in a large animal model and ultimately demonstrate the potential of triggerable tough hydrogels to serve as prolonged gastric resident drug depots. Triggerable tough hydrogels may be applied in myriad of applications, including bariatric interventions, drug delivery, and tissue engineering.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International
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DOI of Published Version
https://doi.org/10.1038/s41467-017-00144-z
