Network Biology of Tumor Stem-like Cells Identified a Regulatory Role of CBX5 in Lung Cancer
Name
Yu-2012-Network biology of.pdf
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Author(s)
Yu, Yau-Hua
Chiou, Guang-Yuh
Huang, Pin-I
Lo, Wen-Liang
Wang, Chien-Ying
Lu, Kai-Hsi
Yu, Cheng-Chia
Alterovitz, Gil
Huang, Wen-Chien
Lo, Jeng-Fan
Date Issued
August 2012
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Yu, Yau-Hua, Guang-Yuh Chiou, Pin-I Huang, Wen-Liang Lo, Chien-Ying Wang, Kai-Hsi Lu, Cheng-Chia Yu, et al. “Network Biology of Tumor Stem-Like Cells Identified a Regulatory Role of CBX5 in Lung Cancer.” Sci. Rep. 2 (August 16, 2012).
Version
Final published version
Abstract
Mounting evidence links cancers possessing stem-like properties with worse prognosis. Network biology with signal processing mechanics was explored here using expression profiles of a panel of tumor stem-like cells (TSLCs). The profiles were compared to their parental tumor cells (PTCs) and the human embryonic stem cells (hESCs), for the identification of gene chromobox homolog 5, CBX5, as a potential target for lung cancer. CBX5 was found to regulate the stem-like properties of lung TSLCs and was predictive of lung cancer prognosis. The investigation was facilitated by finding target genes based on modeling epistatic signaling mechanics via a predictive and scalable network-based survival model. Topologically-weighted measurements of CBX5 were synchronized with those of BIRC5, DNMT1, E2F1, ESR1, MLH1, MSH2, RB1, SMAD1 and TAF5. We validated our findings in another Taiwanese lung cancer cohort, as well as in knockdown experiments using sh-CBX5 RNAi both in vitro and in vivo.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution-NonCommercial-NoDerivs 3.0
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DOI of Published Version
https://doi.org/10.1038/srep00584
