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Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation
Name
e2022422118.full.pdf
Description
Published version
Size
1.04 MB
Format
Adobe PDF
Checksum (MD5)
06bbebf0fe5fb661795900afd718dcb9
Author(s)
Li, Hui
Zheng, Yue
Han, Yu Long
Cai, Shengqiang
Guo, Ming
Date Issued
2021
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
Proceedings of the National Academy of Sciences
Citation
Li, Hui, Zheng, Yue, Han, Yu Long, Cai, Shengqiang and Guo, Ming. 2021. "Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation." Proceedings of the National Academy of Sciences of the United States of America, 118 (11).
Version
Final published version
Abstract
© 2021 National Academy of Sciences. All rights reserved. Basement membrane (BM) is a thin layer of extracellular matrix that surrounds most animal tissues, serving as a physical barrier while allowing nutrient exchange. Although they have important roles in tissue structural integrity, physical properties of BMs remain largely uncharacterized, which limits our understanding of their mechanical functions. Here, we perform pressure-controlled inflation and deflation to directly measure the nonlinear mechanics of BMs in situ. We show that the BMs behave as a permeable, hyperelastic material whose mechanical properties and permeability can be measured in amodel-independent manner. Furthermore, we find that BMs exhibit a remarkable nonlinear stiffening behavior, in contrast to the reconstituted Matrigel. This nonlinear stiffening behavior helps the BMs to avoid the snap-through instability (or structural softening) widely observed during the inflation of most elastomeric balloons and thus maintain sufficient confining stress to the enclosed tissues during their growth.
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DOI of Published Version
10.1073/PNAS.2022422118
