Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface
Name
1251803670-MIT.pdf
Size
7.87 MB
Format
Adobe PDF
Checksum (MD5)
061c28616502a232b40e34db6f7cfbda
Author(s)
Hsu, Chun-Cheng,M. Eng.Massachusetts Institute of Technology.
Advisor(s)
David E. Hardt.
Date Issued
2021
Publisher
Massachusetts Institute of Technology
Abstract
Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte peaks obtained through DESI by improving the temperature uniformity throughout the capillary flow. Multi-channel capillaries were discovered to be more sensitive to temperature and less prone to turbulence under certain conditions when compared to single channel capillaries. A multiple regression analysis reveals the significance of the surface-area-to-volume ratio, inlet-to-outlet area ratio, and the interaction of these main effects with temperature. This study illustrates the complex tradeoff between desolvation and ion loss, thereby providing a general guideline to instrumentation design for the purpose of maximizing signal intensity of the MS.
Description
Thesis: M. Eng. in Advanced Manufacturing and Design, Massachusetts Institute of Technology, Department of Mechanical Engineering, February, 2021
Cataloged from the official PDF of thesis. "February 2021."
Includes bibliographical references (page 53).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
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