CD8⁺ T Cell Response to Influenza Virus
Name
874753595-MIT.pdf
Description
Full printable version
Size
1.02 MB
Format
Adobe PDF
Checksum (MD5)
f766a822c271081d2334d7ecf26a152e
Author(s)
Doty, Daniel, S.M. Massachusetts Institute of Technology
Advisor(s)
Jianzhu Chen.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
The flu is an extremely prevalent and potentially devastating disease, especially dangerous to the very young, the elderly, and to people with compromised immune systems. Influenza has a characteristic course of infection, and is often effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of contraction, when most effector cells die. Those that survive become memory T cells, protecting the body from subsequent influenza infections. The molecular and cellular interactions that comprise the CD8+ cytotoxic T cell response to influenza virus are of particular interest because of their implications for the prevention, treatment, and alleviation of the flu.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2005.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 10-12).
Subjects
Biology.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
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