Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic
Name
Tharakaraman-2013-Antigenically intact hemagglutinin.pdf
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960.7 KB
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Checksum (MD5)
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Author(s)
Tharakaraman, Kannan
Raman, Rahul
Stebbins, Nathan W.
Viswanathan, Karthik
Sasisekharan, Viswanathan
Sasisekharan, Ram
Date Issued
May 2013
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Tharakaraman, Kannan, Rahul Raman, Nathan W. Stebbins, Karthik Viswanathan, Viswanathan Sasisekharan, and Ram Sasisekharan. "Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic." Scientific Reports 2, 2013, 1822.
Version
Final published version
Abstract
The 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be “archived” in the swine species before reemerging in humans. Given that the H3N2 is another subtype that currently circulates in the human population and is high on WHO pandemic preparedness list, we assessed the likelihood of reemergence of H3N2 from a non-human host. Using HA sequence features relevant to immune recognition, receptor binding and transmission we have identified several recent H3 strains in avian and swine that present hallmarks of a reemerging virus. IgG polyclonal raised in rabbit with recent seasonal vaccine H3 fail to recognize these swine H3 strains suggesting that existing vaccines may not be effective in protecting against these strains. Vaccine strategies can mitigate risks associated with a potential H3N2 pandemic in humans.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs 3.0
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DOI of Published Version
https://doi.org/10.1038/srep01822
