Dynamic control of visually guided locomotion through corticosubthalamic projections
Name
1-s2.0-S2211124722009482-main.pdf
Description
Published version
Size
3.06 MB
Format
Adobe PDF
Checksum (MD5)
d21aa605b312df66e9c22cc454a27cef
Author(s)
Adam, Elie M
Johns, Taylor
Sur, Mriganka
Date Issued
2022
Journal
Cell Reports
Publisher
Elsevier BV
Citation
Adam, Elie M, Johns, Taylor and Sur, Mriganka. 2022. "Dynamic control of visually guided locomotion through corticosubthalamic projections." Cell Reports, 40 (4).
Version
Final published version
Abstract
Goal-directed locomotion requires control signals that propagate from higher order areas to regulate spinal mechanisms. The corticosubthalamic hyperdirect pathway offers a short route for cortical information to reach locomotor centers in the brainstem. We developed a task in which head-fixed mice run to a visual landmark and then stop and wait to collect the reward and examined the role of secondary motor cortex (M2) projections to the subthalamic nucleus (STN) in controlling locomotion. Our behavioral modeling, calcium imaging, and optogenetics manipulation results suggest that the M2-STN pathway can be recruited during visually guided locomotion to rapidly and precisely control the pedunculopontine nucleus (PPN) of the mesencephalic locomotor region through the basal ganglia. By capturing the physiological dynamics through a feedback control model and analyzing neuronal signals in M2, PPN, and STN, we find that the corticosubthalamic projections potentially control PPN activity by differentiating an M2 error signal to ensure fast input-output dynamics.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELREP.2022.111139
