Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers
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Langer_Biodegradable microfluidic.pdf
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Author(s)
Wang, Jane
Bettinger, Christopher J.
Langer, Robert
Borenstein, Jeffrey T.
Date Issued
October 2010
Journal
Organogenesis
Publisher
Landes Bioscience
Citation
Wang, Jane, Christopher J. Bettinger, Robert S. Langer, and Jeffrey T. Borenstein 2010 Biodegradable Microfluidic Scaffolds for Tissue Engineering from Amino Alcohol-based Poly(ester Amide) Elastomers. Organogenesis 6(4): 212–216.
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Author's final manuscript
Abstract
Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. Most biodegradable polymers suffer from a short half life due to rapid degradation upon implantation, exceedingly high stiffness, and limited ability to functionalize the surface with chemical moieties. This work describes the fabrication of microfluidic networks from poly(ester amide), poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) (APS), a recently developed biodegradable elastomeric poly(ester amide). Microfluidic scaffolds constructed from APS exhibit a much lower Young’s Modulus and a significantly longer degradation half-life than those of previously reported systems. The device is fabricated using a modified replica-molding technique, which is rapid, inexpensive, reproducible, and scalable, making the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds.
MIT Department
Charles Stark Draper Laboratory
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Program in Polymer Science and Technology
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.4161/org.6.4.12909
