The biological and metabolic fates of endogenous DNA damage products
Name
Chan-2010-The Biological and Metabolic Fates of Endogenous DNA Damage Products.pdf
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867.22 KB
Format
Adobe PDF
Checksum (MD5)
306ea744b22d94f6f2aa206555169ba1
Author(s)
Chan, Wan Simon
Dedon, Peter C.
Date Issued
October 2010
Journal
Journal of Nucleic Acids
Publisher
Hindawi Pub. Corp.
Citation
Chan, Simon Wan, and Peter C. Dedon. “The Biological and Metabolic Fates of Endogenous DNA Damage Products.” Journal of Nucleic Acids 2010 (2010) : 1-13.
Version
Final published version
Abstract
DNA and other biomolecules are subjected to damaging chemical reactions during normal physiological processes and in states of pathophysiology caused by endogenous and exogenous mechanisms. In DNA, this damage affects both the nucleobases and 2-deoxyribose, with a host of damage products that reflect the local chemical pathology such as oxidative stress and inflammation. These damaged molecules represent a potential source of biomarkers for defining mechanisms of pathology, quantifying the risk of human disease and studying interindividual variations in cellular repair pathways. Toward the goal of developing biomarkers, significant effort has been made to detect and quantify damage biomolecules in clinically accessible compartments such as blood and and urine. However, there has been little effort to define the biotransformational fate of damaged biomolecules as they move from the site of formation to excretion in clinically accessible compartments. This paper highlights examples of this important problem with DNA damage products.
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.4061/2010/929047
