Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus
Name
elife-03061-v1.pdf
Size
4.68 MB
Format
Adobe PDF
Checksum (MD5)
b0b06af56693a3ef43169a4da58047b8
Author(s)
Siegle, Joshua Handman
Wilson, Matthew A
Date Issued
July 2014
Journal
eLife
Publisher
eLife Sciences Publications, Ltd
Citation
Siegle, Joshua H and Wilson, Matthew A. "Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus." eLife 2014, 3 (July 2014): e03061 © 2014 Siegle and Wilson
Version
Final published version
Abstract
Assessing the behavioral relevance of the hippocampal theta rhythm has proven difficult, due to a shortage of experiments that selectively manipulate phase-specific information processing. Using closed-loop stimulation, we triggered inhibition of dorsal CA1 at specific phases of the endogenous theta rhythm in freely behaving mice. This intervention enhanced performance on a spatial navigation task that requires the encoding and retrieval of information related to reward location on every trial. In agreement with prior models of hippocampal function, the behavioral effects depended on both the phase of theta and the task segment at which we stimulated. Stimulation in the encoding segment enhanced performance when inhibition was triggered by the peak of theta. Conversely, stimulation in the retrieval segment enhanced performance when inhibition was triggered by the trough of theta. These results suggest that processes related to the encoding and retrieval of task-relevant information are preferentially active at distinct phases of theta.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/eLife.03061.001
