Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA
Name
i2164-2591-14-2-27_1740653651.81209.pdf
Description
Published version
Size
2.77 MB
Format
Adobe PDF
Checksum (MD5)
d59f5b26688b2bb95ba23d86b44ad9b2
Author(s)
Takahashi, Hiroyuki
Hwang, Yunchan
Won, Jungeun
Jamil, Muhammad Usman
Yaghy, Antonio
Liang, Michelle C
Baumal, Caroline R
Witkin, Andre J
Ohno-Matsui, Kyoko
Duker, Jay S
Date Issued
February 28, 2025
Journal
Translational Vision Science & Technology
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Hiroyuki Takahashi, Yunchan Hwang, Jungeun Won, Muhammad Usman Jamil, Antonio Yaghy, Michelle C. Liang, Caroline R. Baumal, Andre J. Witkin, Kyoko Ohno-Matsui, Jay S. Duker, James G. Fujimoto, Nadia K. Waheed; Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA. Trans. Vis. Sci. Tech. 2025;14(2):27.
Version
Final published version
Abstract
Purpose: To quantify the blood flow speed within retinal microaneurysms (MAs) and investigate the relationship between blood flow speed and clinical characteristics in eyes with diabetic retinopathy (DR).
Methods: Variable interscan time analysis (VISTA) quantifies blood flow speed in the vasculature by measuring how fast optical coherence tomography (OCT) angiography (OCTA) saturates for different interscan times. Macular OCTA imaging was performed in eyes with DR using a high-speed swept-source OCT prototype instrument operating at a 600-kHz A-scan rate. The presence of MAs was determined using OCT B-scans, and three-dimensional MA masks were generated. VISTA flow speed (VFS) was determined within MAs and the retinal capillary plexus (RCP). Intraluminal reflectivity, axial location within the RCP, and the presence of intraretinal fluid (IRF) around the MAs were evaluated.
Results: A total of 123 MAs were detected from 24 eyes of 20 patients with DR. Mean VFS was 1.26 ms-1 (95% confidence interval, 1.16-1.35). MAs with medium and high intraluminal reflectivity had slower VFS than those with low intraluminal reflectivity (P < 0.01) and often had slower VFS than the RCP (P < 0.01). Sixty-six MAs were located near IRF and had slower VFS than the other 57 MAs without surrounding IRF (1.16 ms-1 vs. 1.37 ms-1; P = 0.03).
Conclusions: VISTA OCTA can assess blood flow speed of MAs in relation to other structural features in DR. Decreased blood flow speed in MAs is correlated with the presence of IRF around MAs.
Translational Relevance: We offer a new method that quantifies the blood flow speed of MAs to study the development of diabetic macular edema.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1167/tvst.14.2.27
