7.340 Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer, Fall 2006
Author(s)
Randell, John
Tanny, Robyn
Alternative Title
Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer
Date Issued
December 2006
Abstract
In this class we will learn about how the process of DNA replication is regulated throughout the cell cycle and what happens when DNA replication goes awry. How does the cell know when and where to begin replicating its DNA? How does a cell prevent its DNA from being replicated more than once? How does damaged DNA cause the cell to arrest DNA replication until that damage has been repaired? And how is the duplication of the genome coordinated with other essential processes? We will examine both classical and current papers from the scientific literature to provide answers to these questions and to gain insights into how biologists have approached such problems. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
cell
genetic material
cell death
tumorigenesis
mutations
genes
DNA replication
cell cycle
damaged DNA
genome
tumor formation
anti-cancer drugs
viruses
cellular controls
MIT Department
Massachusetts Institute of Technology. Department of Biology
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