Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye
Name
Jia-2015-Quantitative optical.pdf
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2.57 MB
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Checksum (MD5)
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Author(s)
Jia, Yali
Bailey, Steven T.
Hwang, Thomas S.
McClintic, Scott M.
Gao, Simon S.
Pennesi, Mark E.
Flaxel, Christina J.
Lauer, Andreas K.
Wilson, David J.
Hornegger, Joachim
Date Issued
April 2015
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Jia, Yali, Steven T. Bailey, Thomas S. Hwang, Scott M. McClintic, Simon S. Gao, Mark E. Pennesi, Christina J. Flaxel, et al. “Quantitative Optical Coherence Tomography Angiography of Vascular Abnormalities in the Living Human Eye.” Proc Natl Acad Sci USA 112, no. 18 (April 20, 2015): E2395–E2402.
Version
Final published version
Abstract
Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1500185112
