Managing diabetes with nanomedicine: challenges and opportunities
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Anderson_Managing diabetes.pdf
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1.11 MB
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Author(s)
Langer, Robert S
Anderson, Daniel Griffith
Veiseh, Omid
Tang, Benjamin C.
Whitehead, Kathryn Ann
Date Issued
November 2014
Journal
Nature Reviews Drug Discovery
Publisher
Nature Publishing Group
Citation
Veiseh, Omid, Benjamin C. Tang, Kathryn A. Whitehead, Daniel G. Anderson, and Robert Langer. “Managing Diabetes with Nanomedicine: Challenges and Opportunities.” Nature Reviews Drug Discovery 14, no. 1 (November 28, 2014): 45–57.
Version
Author's final manuscript
Abstract
Nanotechnology-based approaches hold substantial potential for improving the care of patients with diabetes. Nanoparticles are being developed as imaging contrast agents to assist in the early diagnosis of type 1 diabetes. Glucose nanosensors are being incorporated in implantable devices that enable more accurate and patient-friendly real-time tracking of blood glucose levels, and are also providing the basis for glucose-responsive nanoparticles that better mimic the body's physiological needs for insulin. Finally, nanotechnology is being used in non-invasive approaches to insulin delivery and to engineer more effective vaccine, cell and gene therapies for type 1 diabetes. Here, we analyse the current state of these approaches and discuss key issues for their translation to clinical practice.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/nrd4477
