A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease
Name
sciadv.aay8828.pdf
Description
Published version
Size
6.56 MB
Format
Adobe PDF
Checksum (MD5)
e38926ff6c0b383ba15d2256cf722d56
Author(s)
Cairns, Dana M
Rouleau, Nicolas
Parker, Rachael N
Walsh, Katherine G
Gehrke, Lee
Kaplan, David L
Date Issued
2020
Journal
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Cairns, Dana M, Rouleau, Nicolas, Parker, Rachael N, Walsh, Katherine G, Gehrke, Lee et al. 2020. "A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease." Science Advances, 6 (19).
Version
Final published version
Abstract
Copyright © 2020 The Authors, Alzheimer’s disease (AD) is a neurodegenerative disorder that causes cognitive decline, memory loss, and inability to perform everyday functions. Hallmark features of AD—including generation of amyloid plaques, neurofibrillary tangles, gliosis, and inflammation in the brain—are well defined; however, the cause of the disease remains elusive. Growing evidence implicates pathogens in AD development, with herpes simplex virus type I (HSV-1) gaining increasing attention as a potential causative agent. Here, we describe a multidisciplinary approach to produce physiologically relevant human tissues to study AD using human-induced neural stem cells (hiNSCs) and HSV-1 infection in a 3D bioengineered brain model. We report a herpes-induced tissue model of AD that mimics human disease with multicellular amyloid plaque–like formations, gliosis, neuroinflammation, and decreased functionality, completely in the absence of any exogenous mediators of AD. This model will allow for future studies to identify potential downstream drug targets for treating this devastating disease.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
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DOI of Published Version
https://doi.org/10.1126/SCIADV.AAY8828
