The Development, Commercialization, and Impact of Optical Coherence Tomography
Name
Fujimoto-2016-The Development, Commercializati.pdf
Size
2.12 MB
Format
Adobe PDF
Checksum (MD5)
4881bfa1162412e20d738eb9070b406a
Author(s)
Fujimoto, James G
Swanson, Eric A
Date Issued
July 2016
Journal
Investigative Opthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology
Citation
Fujimoto, James, and Eric Swanson. “The Development, Commercialization, and Impact of Optical Coherence Tomography.” Investigative Opthalmology & Visual Science 57, no. 9 (July 13, 2016): OCT1.
Version
Final published version
Abstract
This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1167/iovs.16-19963
