Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter
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Fujimoto_Ultrahigh speed.pdf
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Author(s)
Tsai, Tsung-Han
Lee, Hsiang-Chieh
Liang, Kaicheng
Potsaid, Benjamin M.
Tao, Yuankai K.
Jayaraman, Vijaysekhar
Kraus, Martin F.
Hornegger, Joachim
Figueiredo, Marisa
Huang, Qin
Date Issued
March 2014
Journal
Proceedings of SPIE--the International Society for Optical Engineering
Publisher
SPIE
Citation
Tsai, Tsung-Han, Osman O. Ahsen, Hsiang-Chieh Lee, Kaicheng Liang, Michael G. Giacomelli, Benjamin M. Potsaid, Yuankai K. Tao, et al. “Ultrahigh Speed Endoscopic Swept Source Optical Coherence Tomography Using a VCSEL Light Source and Micromotor Catheter.” Edited by Melissa J. Suter, Stephen Lam, Matthew Brenner, Guillermo J. Tearney, and Thomas D. Wang. Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine (March 4, 2014). © 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Version
Final published version
Abstract
We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs Boston Healthcare System (VABHS). Patients with Barrett’s esophagus, dysplasia, and inflammatory bowel disease were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment response.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/12.2040417
