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Prediction of stimulus-independent and task-unrelated thought from functional brain networks
Name
s41467-021-22027-0.pdf
Description
Published version
Size
3.25 MB
Format
Adobe PDF
Checksum (MD5)
7e6518b481a48ffc46f23fa322776705
Author(s)
Kucyi, Aaron
Esterman, Michael
Capella, James
Green, Allison
Uchida, Mai
Biederman, Joseph
Gabrieli, John DE
Valera, Eve M
Whitfield-Gabrieli, Susan
Date Issued
2021
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Kucyi, Aaron, Esterman, Michael, Capella, James, Green, Allison, Uchida, Mai et al. 2021. "Prediction of stimulus-independent and task-unrelated thought from functional brain networks." Nature Communications, 12 (1).
Version
Final published version
Abstract
Neural substrates of “mind wandering” have been widely reported, yet experiments have varied in their contexts and their definitions of this psychological phenomenon, limiting generalizability. We aimed to develop and test the generalizability, specificity, and clinical relevance of a functional brain network-based marker for a well-defined feature of mind wandering—stimulus-independent, task-unrelated thought (SITUT). Combining functional MRI (fMRI) with online experience sampling in healthy adults, we defined a connectome-wide model of inter-regional coupling—dominated by default-frontoparietal control subnetwork interactions—that predicted trial-by-trial SITUT fluctuations within novel individuals. Model predictions generalized in an independent sample of adults with attention-deficit/hyperactivity disorder (ADHD). In three additional resting-state fMRI studies (total n = 1115), including healthy individuals and individuals with ADHD, we demonstrated further prediction of SITUT (at modest effect sizes) defined using multiple trait-level and in-scanner measures. Our findings suggest that SITUT is represented within a common pattern of brain network interactions across time scales and contexts.
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
10.1038/S41467-021-22027-0
