Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans
Name
Pagano-2015-Tissue Expression.pdf
Size
3.05 MB
Format
Adobe PDF
Checksum (MD5)
3e658cc2d1bc941c8ec3baa95f6a4de0
Author(s)
Kim, Dennis H.
Kingston, Elena
Pagano, Daniel Joseph
Date Issued
February 2015
Journal
PLOS Genetics
Publisher
Public Library of Science
Citation
Pagano, Daniel J., Elena R. Kingston, and Dennis H. Kim. “Tissue Expression Pattern of PMK-2 P38 MAPK Is Established by the miR-58 Family in C. Elegans.” PLoS Genet 11, no. 2 (February 11, 2015): e1004997.
Version
Final published version
Abstract
Analyses of gene expression profiles in evolutionarily diverse organisms have revealed a role for microRNAs in tuning tissue-specific gene expression. Here, we show that the relatively abundant and constitutively expressed miR-58 family of microRNAs sharply defines the tissue-specific expression of the broadly transcribed gene encoding PMK-2 p38 MAPK in Caenorhabditis elegans. Whereas PMK-2 functions redundantly with PMK-1 in the nervous system to regulate neuronal development and behavioral responses to pathogenic bacteria, the miR-58, miR-80, miR-81, and miR-82 microRNAs function redundantly to destabilize pmk-2 mRNA in non-neuronal cells with switch-like potency. Our data suggest a role for the miR-58 family in the establishment of neuronal-specific gene expression in C. elegans, and support a more general role for microRNAs in the establishment of tissue-specific gene expression.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1371/journal.pgen.1004997
