Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography
Name
Wei-2013-Parafoveal Retinal V.pdf
Size
1.03 MB
Format
Adobe PDF
Checksum (MD5)
c65487691ec1657e9d23734d85d197d8
Author(s)
Wei, Eric
Jia, Yali
Tan, Ou
Fujimoto, James G.
Huang, David
Potsaid, Benjamin M.
Liu, Jonathan Jaoshin
Choi, Woo Jhon
Date Issued
December 2013
Journal
PLoS ONE
Publisher
Public Library of Science
Citation
Wei, Eric, Yali Jia, Ou Tan, Benjamin Potsaid, Jonathan J. Liu, WooJhon Choi, James G. Fujimoto, and David Huang. “Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography.” Edited by Samuel G. Solomon. PLoS ONE 8, no. 12 (December 2, 2013): e81343.
Version
Final published version
Abstract
We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantify blood flow as measured with parafoveal flow index (PFI), which is proportional to the density of blood vessels and the velocity of blood flow in the parafoveal region of the macula. PFI measurements were taken in 15 second intervals during a 4 minute period consisting of 1 minute of baseline, 2 minutes with an 8 Hz reversing checkerboard pattern stimulation, and 1 minute without stimulation. PFI measurements increased 6.1±4.7% (p = .001) during the first minute of stimulation, with the most significant increase in PFI occurring 30 seconds into stimulation (p<0.001). These results suggest that pattern stimulation induces a change to retinal blood flow that can be reliably measured with OCT angiography.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Publisher with Creative Commons License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1371/journal.pone.0081343
