Complementary Cost‐Effective Electrochemical Platforms for Point‐Of‐Use Biosensing
Name
Advanced Sensor Research - 2024 - Monaco - Complementary Cost‐Effective Electrochemical Platforms for Point‐Of‐Use.pdf
Description
Published version
Size
1.57 MB
Format
Adobe PDF
Checksum (MD5)
82e785380e4b9dadb6ca8172bd9f19f9
Author(s)
Monaco, Mason
Zamani, Marjon
Sarram, Ava
Kuo, Chao‐Chi
Abeyrathne, Chathurika
Li, Miaosi
Furst, Ariel L
Date Issued
February 2025
Journal
Advanced Sensor Research
Publisher
Wiley
Citation
Monaco, Mason, Zamani, Marjon, Sarram, Ava, Kuo, Chao‐Chi, Abeyrathne, Chathurika et al. 2025. "Complementary Cost‐Effective Electrochemical Platforms for Point‐Of‐Use Biosensing." Advanced Sensor Research, 4 (2).
Version
Final published version
Abstract
The COVID‐19 pandemic has illustrated the urgent need for rapid and affordable point‐of‐use diagnostics. Electrochemical biosensors are useful for such applications because they enable quantitative readout and show drastically improved sensitivity compared to prevalent lateral flow technologies. However, to‐date, the poor quality of commercially‐available, mass‐produced electrodes has prohibited the scaled production and commercialization of such biosensors beyond glucose sensing. Low‐cost gold leaf electrodes have previously been developed that can be fabricated with no specialized equipment at the point‐of‐use. These electrodes are more effective for biosensing than prevalent commercially‐available systems. Yet, their manual fabrication can be tedious and is not scalable in its current form. Here, performance of mass‐produced gold electrodes generated using roll‐to‐roll manufacturing is evaluated, offering the potential to scale production. Upon comparison of these electrodes with the gold leaf, it is found that these electrodes are high quality, equivalent to the gold leaf electrodes, and support biosensing applications through the detection of both DNase I and BtsI‐v2 activity with comparable performance. These results demonstrate the role of complementary technologies to achieve point‐of‐use sensing by enabling flexibility between mass‐produced manufacture and on‐site production.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adsr.202400058
