Chip-Based Resonance Raman Spectroscopy Using Tantalum Pentoxide Waveguides
Name
08709965.pdf
Description
Published version
Size
781.16 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Coucheron, David A.
Wadduwage, Dushan Nawoda
Murugan, G. Senthil
So, Peter T. C.
Ahluwalia, Balpreet S.
Date Issued
May 2019
Journal
IEEE Photonics Technology Letters
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Citation
Coucheron, David A. et al. "Chip-Based Resonance Raman Spectroscopy Using Tantalum Pentoxide Waveguides." IEEE Photonics Technology Letters 31, 14 (July 2019): 1127 - 1130
Version
Final published version
Abstract
Blood analysis is an important diagnostic tool, as it provides a wealth of information about the patient's health. Raman spectroscopy is a promising tool for blood analysis, but widespread clinical application is limited by its low signal strength, as well as complex and costly instrumentation. The growing field of waveguide-based Raman spectroscopy tries to solve these challenges by working toward fully integrated Raman sensors with increased interaction areas. In this letter, we demonstrate resonance Raman measurements of hemoglobin, a crucial component of blood, at 532-nm excitation using a tantalum pentoxide (Ta₂O₅) waveguide platform. We have also characterized the background signal from Ta₂O5 waveguide material when excited at 532 nm. In addition, we demonstrate spontaneous Raman measurements of isopropanol and methanol using the same platform. Our results suggest that Ta₂O₅ is a promising waveguide platform for resonance Raman spectroscopy at 532 nm and, in particular, for blood analysis.
MIT Department
Massachusetts Institute of Technology. Laser Biomedical Research Center
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 3.0 unported license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/lpt.2019.2915671
