Titration Microcalorimetry Study: Interaction of Drug and Ionic Microgel System
Name
MEBCS028.pdf
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212.86 KB
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Checksum (MD5)
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Author(s)
Tian, Y.
Tam, Michael K. C.
Hatton, T. Alan
Bromberg, Lev
Date Issued
January 2004
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Doxorubicin (DOX) and Pluronic-PAA interaction was investigated using isothermal titration calorimetry (ITC). DOX/polymer interaction is governed primarily by electrostatic interaction. The uptake of DOX results in the formation of insoluble polymer/DOX complex. Addition of salt weakens the interaction of drug and polymer by charge shielding effect between positive ionized amino group on DOX and oppositely charged polymer chains. However high drug-loading capacity in high salt condition implied that self-association property of DOX also play a role in the drug loading process.
Subjects
anticancer drug
ionic microgel
electrostatic interaction
hydrophobic interaction
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