Decreasing Herpes Simplex Viral Infectivity in Solution by Surface-Immobilized and Suspended N,N-Dodecyl,methyl-polyethylenimine
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Klibanov_Decreasing herpes.pdf
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Author(s)
Larson, Alyssa Maxine
Oh, Hyung Suk
Knipe, David M.
Klibanov, Alexander M.
Date Issued
July 2012
Journal
Pharmaceutical Research
Publisher
Springer-Verlag
Citation
Larson, Alyssa M., Hyung Suk Oh, David M. Knipe, and Alexander M. Klibanov. “Decreasing Herpes Simplex Viral Infectivity in Solution by Surface-Immobilized and Suspended N,N-Dodecyl,methyl-Polyethylenimine.” Pharmaceutical Research 30, no. 1 (July 14, 2012): 25–31.
Version
Author's final manuscript
Abstract
Purpose
To explore surface-immobilized and suspended modalities of the hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI) for the ability to reduce viral infectivity in aqueous solutions containing herpes simplex viruses (HSVs) 1 and 2.
Methods
Surface-immobilized (coated onto surfaces) and suspended DMPEI were incubated with aqueous solutions containing HSV-1 or -2 to measure the antiviral effect of the hydrophobic polycation’s formulations on HSVs.
Results
DMPEI coated on either polyethylene slides or male latex condoms dramatically decreases infectivity in solutions containing HSV-1 or -2. Moreover, DMPEI suspended in aqueous solution markedly reduces the infectious titer of these HSVs.
Conclusion
Our results suggest potential uses of DMPEI for both prophylaxis (in the form of coated condoms) and treatment (as a topical suspension) for HSV infections.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/s11095-012-0825-2
