Motility of Different Gastric Helicobacter spp.
Name
microorganisms-11-00634-v2.pdf
Size
2.7 MB
Format
Adobe PDF
Checksum (MD5)
d401aea13903a3d21dc98931e5284f32
Author(s)
Bansil, Rama
Constantino, Maira A.
Su-Arcaro, Clover
Liao, Wentian
Shen, Zeli
Fox, James G.
Date Issued
March 1, 2023
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Microorganisms 11 (3): 634 (2023)
Version
Final published version
Abstract
Helicobacter spp., including the well-known human gastric pathogen H. pylori, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different Helicobacter spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All Helicobacter spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of H. pylori varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of H. suis, which has bipolar flagella, is more complex than that of unipolar H. pylori. H. suis exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of Helicobacter spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/microorganisms11030634
