The 4D nucleome project
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Mirny_The 4d nucleome project.pdf
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462.44 KB
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Author(s)
Dekker, Job
Belmont, Andrew S.
Guttman, Mitchell
Leshyk, Victor O.
Lis, John T.
Lomvardas, Stavros
O’Shea, Clodagh C.
Park, Peter J.
Ren, Bing
Politz, Joan C. Ritland
Date Issued
September 2017
Journal
Nature
Publisher
Nature Publishing Group
Citation
Dekker, Job et al. “The 4D Nucleome Project.” Nature 549, no. 7671 (September 2017): 219–226 © 2017 Macmillan Publishers Limited, part of Springer Nature
Version
Author's final manuscript
Abstract
The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.
MIT Department
Institute for Medical Engineering and Science
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/NATURE23884
