Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells
Name
Sun-2015-Distinct speed.pdf
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1.22 MB
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Checksum (MD5)
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Author(s)
Sun, Chen
Kitamura, Takashi
Yamamoto, Jun
Martin, Jared
Kitch, Lacey J.
Schnitzer, Mark J.
Tonegawa, Susumu
Pignatelli di Spinazzola, Michele
Date Issued
July 2015
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Sun, Chen, Takashi Kitamura, Jun Yamamoto, Jared Martin, Michele Pignatelli, Lacey J. Kitch, Mark J. Schnitzer, and Susumu Tonegawa. “Distinct Speed Dependence of Entorhinal Island and Ocean Cells, Including Respective Grid Cells.” Proc Natl Acad Sci USA 112, no. 30 (July 13, 2015): 9466–9471.
Version
Final published version
Abstract
Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II contains pyramidal island and stellate ocean cells. Here, we performed cell type-specific Ca[superscript 2+] imaging in freely exploring mice using cellular markers and a miniature head-mounted fluorescence microscope. We found that both oceans and islands contain grid cells in similar proportions, but island cell activity, including activity in a proportion of grid cells, is significantly more speed modulated than ocean cell activity. We speculate that this differential property reflects island cells’ and ocean cells’ contribution to different downstream functions: island cells may contribute more to spatial path integration, whereas ocean cells may facilitate contextual representation in downstream circuits.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1511668112
