Biodegradable Polymeric Micro/Nano-Structures with Intrinsic Antifouling/Antimicrobial Properties: Relevance in Damaged Skin and Other Biomedical Applications
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jfb-11-00060-v3.pdf
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3.28 MB
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Checksum (MD5)
d82a3335ec91034a317c4a75ab50b8b1
Author(s)
Milazzo, Mario
Gallone, Giuseppe
Marcello, Elena
Mariniello, Maria Donatella
Bruschini, Luca
Roy, Ipsita
Danti, Serena
Date Issued
August 2020
Journal
Journal of Functional Biomaterials
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Milazzo, Mario et al. "Biodegradable Polymeric Micro/Nano-Structures with Intrinsic Antifouling/Antimicrobial Properties: Relevance in Damaged Skin and Other Biomedical Applications." Journal of Functional Biomaterials 11, 3 (August 2020): 60 ©2020 Author(s)
Version
Final published version
Abstract
Bacterial colonization of implanted biomedical devices is the main cause of healthcare-associated infections, estimated to be 8.8 million per year in Europe. Many infections originate from damaged skin, which lets microorganisms exploit injuries and surgical accesses as passageways to reach the implant site and inner organs. Therefore, an effective treatment of skin damage is highly desirable for the success of many biomaterial-related surgical procedures. Due to gained resistance to antibiotics, new antibacterial treatments are becoming vital to control nosocomial infections arising as surgical and post-surgical complications. Surface coatings can avoid biofouling and bacterial colonization thanks to biomaterial inherent properties (e.g., super hydrophobicity), specifically without using drugs, which may cause bacterial resistance. The focus of this review is to highlight the emerging role of degradable polymeric micro- and nano-structures that show intrinsic antifouling and antimicrobial properties, with a special outlook towards biomedical applications dealing with skin and skin damage. The intrinsic properties owned by the biomaterials encompass three main categories: (1) physical–mechanical, (2) chemical, and (3) electrostatic. Clinical relevance in ear prostheses and breast implants is reported. Collecting and discussing the updated outcomes in this field would help the development of better performing biomaterial-based antimicrobial strategies, which are useful to prevent infections.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/jfb11030060
