Prolonged dopamine signalling in striatum signals proximity and value of distant rewards
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Graybiel_Prolonged dopamine.pdf
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Author(s)
Howe, Mark William
Sandberg, Stefan G.
Phillips, Paul E. M.
Graybiel, Ann M.
Tierney, Patrick
Date Issued
August 2013
Journal
Nature
Publisher
Nature Publishing Group
Citation
Howe, Mark W., Patrick L. Tierney, Stefan G. Sandberg, Paul E. M. Phillips, and Ann M. Graybiel. “Prolonged Dopamine Signalling in Striatum Signals Proximity and Value of Distant Rewards.” Nature 500, no. 7464 (August 4, 2013): 575–579.
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Author's final manuscript
Abstract
Predictions about future rewarding events have a powerful influence on behaviour. The phasic spike activity of dopamine-containing neurons, and corresponding dopamine transients in the striatum, are thought to underlie these predictions, encoding positive and negative reward prediction errors. However, many behaviours are directed towards distant goals, for which transient signals may fail to provide sustained drive. Here we report an extended mode of reward-predictive dopamine signalling in the striatum that emerged as rats moved towards distant goals. These dopamine signals, which were detected with fast-scan cyclic voltammetry (FSCV), gradually increased or—in rare instances—decreased as the animals navigated mazes to reach remote rewards, rather than having phasic or steady tonic profiles. These dopamine increases (ramps) scaled flexibly with both the distance and size of the rewards. During learning, these dopamine signals showed spatial preferences for goals in different locations and readily changed in magnitude to reflect changing values of the distant rewards. Such prolonged dopamine signalling could provide sustained motivational drive, a control mechanism that may be important for normal behaviour and that can be impaired in a range of neurologic and neuropsychiatric disorders.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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DOI of Published Version
https://doi.org/10.1038/nature12475
