Delta oscillations phase limit neural activity during sevoflurane anesthesia
Name
s42003-019-0664-3.pdf
Description
Published version
Size
3.05 MB
Format
Adobe PDF
Checksum (MD5)
ef759d8690c54e77eab483585bec9753
Author(s)
Chamadia, Shubham
Pedemonte, Juan C
Hahm, Eunice Y
Mekonnen, Jennifer
Ibala, Reine
Gitlin, Jacob
Ethridge, Breanna R
Qu, Jason
Vazquez, Rafael
Rhee, James
Date Issued
2019
Journal
Communications Biology
Publisher
Springer Science and Business Media LLC
Version
Final published version
Abstract
© 2019, The Author(s). Understanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscillations have been postulated as a mechanism of sevoflurane general anesthesia. This postulate remains unproven. Therefore, we performed a single-site, randomized, cross-over, high-density electroencephalogram study of sevoflurane and sevoflurane-plus-ketamine general anesthesia in 12 healthy subjects. Data were analyzed with multitaper spectral, global coherence, cross-frequency coupling, and phase-dependent methods. Our results suggest that coherent alpha oscillations are not fundamental for maintaining sevoflurane general anesthesia. Taken together, our results suggest that subanesthetic and general anesthetic sevoflurane brain states emerge from impaired information processing instantiated by a delta-higher frequency phase-amplitude coupling syntax. These results provide fundamental new insights into the neural circuit mechanisms of sevoflurane anesthesia and suggest that anesthetic states may be produced by extracranial perturbations that cause delta-higher frequency phase-amplitude interactions.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Institute for Data, Systems, and Society
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
10.1038/S42003-019-0664-3
https://doi.org/10.1038/S42003-019-0664-3
