Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device
Name
sensors-21-01366-v2.pdf
Size
2.04 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Kim, Jaehoon
Yoon, Junghyo
Byun, Jae-Yeong
Kim, Hyunho
Han, Sewoon
Kim, Junghyun
Lee, Jeong Hoon
Jo, Han-Sang
Chung, Seok
Date Issued
February 15, 2021
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Sensors 21 (4): 1366 (2021)
Version
Final published version
Abstract
Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μL of extracted plasma with a high extraction yield (~45%) in 16 min.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/s21041366
