Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis
Name
1-s2.0-S0896627320304396-main.pdf
Description
Published version
Size
3.85 MB
Format
Adobe PDF
Checksum (MD5)
20ab91735b364aec3cd83ce5ac979dfb
Author(s)
Roussarie, Jean-Pierre
Yao, Vicky
Rodriguez-Rodriguez, Patricia
Oughtred, Rose
Rust, Jennifer
Plautz, Zakary
Kasturia, Shirin
Albornoz, Christian
Wang, Wei
Schmidt, Eric F
Date Issued
2020
Journal
Neuron
Publisher
Elsevier BV
Citation
Roussarie, Jean-Pierre, Yao, Vicky, Rodriguez-Rodriguez, Patricia, Oughtred, Rose, Rust, Jennifer et al. 2020. "Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis." Neuron, 107 (5).
Version
Final published version
Abstract
© 2020 The Authors Neurons display different levels of vulnerability to Alzheimer's pathology. Roussarie et al. experimentally profile and computationally model several relevant neuron types. Using a mouse-human framework, they identify genes linking Aß, aging, and tau in vulnerable neurons. Finally, they show experimentally that PTB, a regulator of tau splicing, contributes to vulnerability.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NEURON.2020.06.010
