Dietary Microbes Modulate Transgenerational Cancer Risk
Name
Alm_Dietary microbes.pdf
Size
2.66 MB
Format
Adobe PDF
Checksum (MD5)
398d756b441ae948af5b2bcc06bec68c
Author(s)
Chatzigiagkos, A.
Kearney, Sean M
Alm, Eric J
Poutahidis, Theofilos
Varian, Bernard
Urman, Tatiana
Lakritz, Jessica
Mirabal, Sheyla
Kwok, Caitlin
Ibrahim, Yassin M
Date Issued
February 2015
Journal
Cancer Research
Publisher
American Association for Cancer Research
Citation
Poutahidis, T. et al. “Dietary Microbes Modulate Transgenerational Cancer Risk.” Cancer Research 75.7 (2015): 1197–1204.
Version
Author's final manuscript
Abstract
Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1158/0008-5472.can-14-2732
