Bioengineered Probes for Molecular Magnetic Resonance Imaging in the Nervous System
Name
Hsieh2012ACSChemNeuro_all704.pdf
Description
Main article
Size
10.74 MB
Format
Adobe PDF
Checksum (MD5)
01dcc96707c20b7beaebbcfde8d69175
Author(s)
Jasanoff, Alan Pradip
Hsieh, David
Date Issued
July 2012
Journal
ACS Chemical Neuroscience
Publisher
American Chemical Society (ACS)
Citation
Hsieh, Vivian, and Alan Jasanoff. “Bioengineered Probes for Molecular Magnetic Resonance Imaging in the Nervous System.” ACS Chemical Neuroscience 3, no. 8 (August 15, 2012): 593–602.
Version
Author's final manuscript
Abstract
The development of molecular imaging probes has changed the nature of neurobiological research. Some of the most notable successes have involved the use of biological engineering techniques for the creation of fluorescent protein derivatives for optical imaging, but recent work has also led to a number of bioengineered probes for magnetic resonance imaging (MRI), the preeminent technique for noninvasive investigation of brain structure and function. Molecular MRI agents are beginning to be applied for experiments in the nervous system, where they have the potential to bridge from molecular to systems or organismic levels of analysis. Compared with canonical synthetic small molecule agents, biomolecular or semibiosynthetic MRI contrast agents offer special advantages due to their amenability to molecular engineering approaches, their properties in some cases as catalysts, and their specificity in targeting and ligand binding. Here, we discuss an expanding list of instances where biological engineering techniques have aided in the design of MRI contrast agents and reporter systems, examining both advantages and limitations of these types of probes for studies in the central nervous system.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/cn300059r
