Preserved functional organization of auditory cortex in two individuals missing one temporal lobe from infancy
Name
PIIS2589004224017735.pdf
Description
Published version
Size
4.86 MB
Format
Adobe PDF
Checksum (MD5)
7c23a719ddf23b4de91ed465594c83b8
Author(s)
Regev, Tamar I
Lipkin, Benjamin
Boebinger, Dana
Paunov, Alexander
Kean, Hope
Norman-Haignere, Sam V
Fedorenko, Evelina
Date Issued
September 2024
Journal
iScience
Publisher
Elsevier BV
Citation
Regev, Tamar I. et al. Preserved functional organization of auditory cortex in two individuals missing one temporal lobe from infancy. iScience, Volume 27, Issue 9, 110548
Version
Final published version
Abstract
Human cortical responses to natural sounds, measured with fMRI, can be approximated as the weighted sum of a small number of canonical response patterns (components), each having interpretable functional and anatomical properties. Here, we asked whether this organization is preserved in cases where only one temporal lobe is available due to early brain damage by investigating a unique family: one sibling missing their left temporal lobe from infancy, another missing the right temporal lobe from infancy, and a third anatomically neurotypical. None of the siblings manifested behavioral deficits. We analyzed fMRI responses to diverse natural sounds within the intact hemispheres of these individuals and compared them to 12 neurotypical participants. All siblings manifested typical-like auditory responses in their intact hemispheres. These results suggest that the development of the auditory cortex in each hemisphere does not depend on the existence of the other hemisphere, highlighting the redundancy and equipotentiality of the bilateral auditory system.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.isci.2024.110548
