Molecular approaches for manipulating astrocytic signaling in vivo
Name
Xie-2015-Molecular approaches.pdf
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1017.61 KB
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6343e170bcdb93fc4b18889b8f880007
Author(s)
Xie, Alison X.
McCarthy, Ken D.
Petravicz, Jeremy C.
Date Issued
April 2015
Journal
Frontiers in Cellular Neuroscience
Publisher
Frontiers Research Foundation
Citation
Xie, Alison X., Jeremy Petravicz, and Ken D. McCarthy. “Molecular Approaches for Manipulating Astrocytic Signaling in Vivo.” Frontiers in Cellular Neuroscience 9 (April 21, 2015).
Version
Final published version
Abstract
Astrocytes are the predominant glial type in the central nervous system and play important roles in assisting neuronal function and network activity. Astrocytes exhibit complex signaling systems that are essential for their normal function and the homeostasis of the neural network. Altered signaling in astrocytes is closely associated with neurological and psychiatric diseases, suggesting tremendous therapeutic potential of these cells. To further understand astrocyte function in health and disease, it is important to study astrocytic signaling in vivo. In this review, we discuss molecular tools that enable the selective manipulation of astrocytic signaling, including the tools to selectively activate and inactivate astrocyte signaling in vivo. Lastly, we highlight a few tools in development that present strong potential for advancing our understanding of the role of astrocytes in physiology, behavior, and pathology.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fncel.2015.00144
