The 3D Genome as Moderator of Chromosomal Communication
Name
nihms-759042.pdf
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1.07 MB
Format
Adobe PDF
Checksum (MD5)
4ed25e6e8d67e69a8782fbdc9c73a1fa
Author(s)
Dekker, Job
Mirny, Leonid A
Date Issued
March 2016
Journal
Cell
Publisher
Elsevier
Citation
Dekker, Job, and Mirny, Leonid. “The 3D Genome as Moderator of Chromosomal Communication.” Cell 164, 6 (March 2016): 1110–1121 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.
MIT Department
Institute for Medical Engineering and Science
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELL.2016.02.007
