Zebrafish as a model to study live mucus physiology
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Jevtov-2014-Zebrafish as a model.pdf
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Author(s)
Jevtov, Irena
Samuelsson, Tore
Yao, Grace
Amsterdam, Adam
Ribbeck, Katharina
Date Issued
October 2014
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Jevtov, Irena, Tore Samuelsson, Grace Yao, Adam Amsterdam, and Katharina Ribbeck. “Zebrafish as a Model to Study Live Mucus Physiology.” Sci. Rep. 4 (October 17, 2014): 6653.
Version
Final published version
Abstract
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1038/srep06653
