Lamination of a biodegradable polymeric microchip
Name
71844557-MIT.pdf
Description
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984.45 KB
Format
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Checksum (MD5)
655952bcdc9c4cef0a2e62fa909306fc
Author(s)
Kim, Jina, 1984-
Advisor(s)
Michael J. Cima.
Date Issued
2006
Publisher
Massachusetts Institute of Technology
Abstract
This work builds on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs that are fabricated via lamination, and a final design was proposed based on the results. Design 1 sought to replace the sealant directly with a PLA backing layer, but the laminated backing layer was found to leak in 14C-dextran release experiments. Design 2 used a laminated film instead of the original injected membrane. The laminated film was optimized to a 200- [mu]m thick poly(D,L-lactic-co-glycolic acid) 2A membrane, and the film-laminated microchip was shown to release 14C-dextran within a 40-day period. The final proposed design was based on Design 2, which demonstrated more potential as a future means of drug delivery.
Description
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.
Includes bibliographical references (leaf 22).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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