Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells
Name
Jaenisch_Pan-Src Family.pdf
Size
893.77 KB
Format
Adobe PDF
Checksum (MD5)
461a2482a705eb3d18450184f543a964
Author(s)
Staerk, Judith
Lyssiotis, Costas A.
Medeiro, Lea A.
Bollong, Michael
Foreman, Ruth K.
Zhu, Shoutian
Garcia, Michael
Gao, Qing
Bouchez, Laure C.
Lairson, Luke L.
Date Issued
May 2011
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell (John Wiley & Sons)
Citation
Staerk, Judith et al. “Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells.” Angewandte Chemie International Edition 50.25 (2011): 5734–5736.
Version
Author's final manuscript
Abstract
Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201101042
