Grounded: Transcriptional Pausing in Naive mESCs
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Guenther-2012-Grounded_ Transcript.pdf
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Author(s)
Guenther, Matthew G.
Young, Richard A.
Young, Richard A.
Date Issued
May 2012
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Guenther, Matthew G., and Richard A. Young. “Grounded: Transcriptional Pausing in Naive mESCs.” Cell Stem Cell 10, no. 5 (May 2012): 484–485. © 2012 Elsevier Inc.
Version
Final published version
Abstract
Growing mouse pluripotent stem cells in defined media with signaling inhibitors establishes a naive ground state different from that of cells grown in serum. Recently in Cell, Marks et al. (2012) reported differences in the transcriptional and epigenomic landscapes of naive and serum-exposed mouse stem cells that improve our understanding of the pluripotent ground state.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.stem.2012.04.016
