Approaches to in vitro tissue regeneration with application for human disease modeling and drug development
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Lauffenburger_Approaches to in vitro.pdf
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Author(s)
Young, Carissa L.
Lauffenburger, Douglas A.
Griffith, Linda G.
Borenstein, Jeffrey T.
Ebrahimkhani, Mohammad Reza
Date Issued
May 2014
Journal
Drug Discovery Today
Publisher
Elsevier
Citation
Ebrahimkhani, Mohammad R., Carissa L. Young, Douglas A. Lauffenburger, Linda G. Griffith, and Jeffrey T. Borenstein. “Approaches to in Vitro Tissue Regeneration with Application for Human Disease Modeling and Drug Development.” Drug Discovery Today 19, no. 6 (June 2014): 754–762.
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Author's final manuscript
Abstract
Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science.
MIT Department
Massachusetts Institute of Technology. Center for Gynepathology Research
Massachusetts Institute of Technology. Department of Biological Engineering
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DOI of Published Version
https://doi.org/10.1016/j.drudis.2014.04.017
