3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture
Name
nihms523151.pdf
Description
Accepted version
Size
2.03 MB
Format
Adobe PDF
Checksum (MD5)
d606679c39accc0e3c25ac71394d9d21
Author(s)
Kolewe, Martin E.
Park, Hyoungshin
Gray, Caprice
Ye, Xiaofeng
Langer, Robert
Freed, Lisa E.
Date Issued
August 2013
Journal
Advanced materials
Publisher
Wiley
Citation
Kolewe, Martin E., et al., "3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture." Advanced materials 25, 32 (August 2013): p. 4459-65 doi 10.1002/ADMA.201301016 ©2013 Author(s)
Version
Author's final manuscript
Abstract
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ©2013
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADMA.201301016
