Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT
Name
i1552-5783-65-10-18_1723113658.53429.pdf
Description
Published version
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11.05 MB
Format
Adobe PDF
Checksum (MD5)
5ac66fac6fd01a0e0a38d0d4080db43e
Author(s)
Won, Jungeun
Takahashi, Hiroyuki
Ploner, Stefan B
Karbole, Wenke
Abu-Qamar, Omar
Yaghy, Antonio
Marmalidou, Anna
Kaiser, Stephanie
Hwang, Yunchan
Lin, Junhong
Date Issued
August 9, 2024
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Jungeun Won, Hiroyuki Takahashi, Stefan B. Ploner, Wenke Karbole, Omar Abu-Qamar, Antonio Yaghy, Anna Marmalidou, Stephanie Kaiser, Yunchan Hwang, Junhong Lin, Andre Witkin, Shilpa Desai, Caroline R. Baumal, Andreas Maier, Christine A. Curcio, Nadia K. Waheed, James G. Fujimoto; Topographic Measurement of the Subretinal Pigment Epithelium Space in Normal Aging and Age-Related Macular Degeneration Using High-Resolution OCT. Invest. Ophthalmol. Vis. Sci. 2024;65(10):18.
Version
Final published version
Abstract
Purpose: A micrometer scale hyporeflective band within the retinal pigment epithelium basal lamina - Bruch's membrane complex (RPE-BL-BrM) was topographically measured in aging and age-related macular degeneration (AMD).
Methods: In a prospective cross-sectional study, 90 normal eyes from 76 subjects (range = 23-90 years) and 53 dry AMD eyes from 47 subjects (range = 62-91 years) were enrolled. Isotropic volume raster scans over 6 mm × 6 mm (500 × 500 A-scans) were acquired using a high-resolution (2.7 µm axial resolution) spectral-domain optical coherence tomography (SD-OCT) prototype instrument. Six consecutive optical coherence tomography (OCT) volumes were computationally motion-corrected and fused to improve feature visibility. A boundary regression neural network was developed to measure hyporeflective band thickness. Topographic dependence was evaluated over a 6-mm-diameter Early Treatment Diabetic Retinopathy Study (ETDRS) grid.
Results: The hyporeflective band thickness map (median of 4.3 µm and 7.8 µm in normal and AMD eyes, respectively) is thicker below and radially symmetric around the fovea. In normal eyes, age-associated differences occur within 0.7 to 2.3 mm from the foveal center (P < 0.05). In AMD eyes, the hyporeflective band is hypothesized to be basal laminar deposits (BLamDs) and is thicker within the 3-mm ETDRS circle (P < 0.0002) compared with normal eyes. The inner ring is the most sensitive location to detect age versus AMD-associated changes within the RPE-BL-BrM. AMD eyes with subretinal drusenoid deposits (SDDs) have a significantly thicker hyporeflective band (P < 0.001) than those without SDDs.
Conclusions: The hyporeflective band is a quantifiable biomarker which differentiates AMD from aging. Longitudinal studies are warranted. The hyporeflective band may be a useful biomarker for risk stratification and disease progression.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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Creative Commons Attribution-NonCommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1167/iovs.65.10.18
