Island Cells Control Temporal Association Memory
Name
Island Cells Control Temporal[1].pdf
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1.09 MB
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Author(s)
Kitamura, Takashi
Suh, Junghyup
Kohara, Keigo
Tonegawa, Susumu
Yoshiki, Atsushi
Abe, Kuniya
Pignatelli di Spinazzola, Michele
Date Issued
January 2014
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Kitamura, T., M. Pignatelli, J. Suh, K. Kohara, A. Yoshiki, K. Abe, and S. Tonegawa. “Island Cells Control Temporal Association Memory.” Science 343, no. 6173 (February 21, 2014): 896–901.
Version
Author's final manuscript
Abstract
Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.1244634
