Generation, Translocation, and Action of Nitric Oxide in Living Systems
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Tennyson-2011-Generation, Transloc.pdf
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679.47 KB
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Author(s)
Tennyson, Andrew G.
Lippard, Stephen J.
Date Issued
October 2011
Journal
Chemistry & Biology
Publisher
Elsevier B.V.
Citation
Tennyson, Andrew G., and Stephen J. Lippard. “Generation, Translocation, and Action of Nitric Oxide in Living Systems.” Chemistry & Biology 18, no. 10 (October 2011): 1211–1220. © 2011 Elsevier Ltd.
Version
Final published version
Abstract
Nitric oxide (NO) is a gaseous diatomic radical that is involved in a wide range of physiological and pathological functions in biology. Conceptually, the biochemistry of NO can be separated into three stages: generation (stage 1), translocation (stage 2), and action (stage 3). In stage 1 the oxygenase domain of NO synthase converts L-arginine to L-citrulline and NO (g). Owing to its short-lived nature, this molecule is converted into a different nitrogen oxide such as NO[subscript 2], an organonitrosyl such as a nitrosothiol, or a metal nitrosyl such as a heme-nitrosyl, for transportation in stage 2. Each of these derivatives features unique physical characteristics, chemical reactivity, and biological activity. Upon delivery in stage 3, NO exerts its physiological or pathological function by reaction with biomolecules containing redox-active metals or other residues.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.chembiol.2011.09.009
