Functional gradients of the cerebellum
Name
elife-36652-v1.pdf
Size
3.26 MB
Format
Adobe PDF
Checksum (MD5)
9e211f0e7858077bc6341f4d21921688
Author(s)
Schmahmann, Jeremy D
Guell Paradis, Xavier
Gabrieli, John D. E.
Ghosh, Satrajit S
Date Issued
August 2018
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Guell, Xavier, Jeremy D Schmahmann, John DE Gabrieli, and Satrajit S Ghosh. “Functional Gradients of the Cerebellum.” eLife 7 (August 14, 2018).
Version
Final published version
Abstract
A central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map embedding to resting-state data from the Human Connectome Project dataset (n = 1003), and show for the first time that cerebellar functional regions follow a gradual organization which progresses from primary (motor) to transmodal (DMN, task-unfocused) regions. A secondary axis extends from task-unfocused to task-focused processing. Further, these two principal gradients revealed novel functional properties of the well-established cerebellar double motor representation (lobules I-VI and VIII), and its relationship with the recently described triple nonmotor representation (lobules VI/Crus I, Crus II/VIIB, IX/X). Functional differences exist not only between the two motor but also between the three nonmotor representations, and second motor representation might share functional similarities with third nonmotor representation.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Clinical Research Center
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Research Laboratory of Electronics
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/eLife.36652
