Effect of sequence features on assembly of spider silk block copolymers
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Buehler_Effect of.pdf
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3.21 MB
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Author(s)
Tokareva, Olena S.
Lin, Shangchao
Jacobsen, Matthew M.
Huang, Wenwen
Rizzo, Daniel
Li, David
Simon, Marc
Staii, Cristian
Cebe, Peggy
Wong, Joyce Y.
Date Issued
March 2014
Journal
Journal of Structural Biology
Publisher
Elsevier
Citation
Tokareva, Olena S., Shangchao Lin, Matthew M. Jacobsen, Wenwen Huang, Daniel Rizzo, David Li, Marc Simon, et al. “Effect of Sequence Features on Assembly of Spider Silk Block Copolymers.” Journal of Structural Biology 186, no. 3 (June 2014): 412–419.
Version
Author's final manuscript
Abstract
Bioengineered spider silk block copolymers were studied to understand the effect of protein chain length and sequence chemistry on the formation of secondary structure and materials assembly. Using a combination of in vitro protein design and assembly studies, we demonstrate that silk block copolymers possessing multiple repetitive units self-assemble into lamellar microstructures. Additionally, the study provides insights into the assembly behavior of spider silk block copolymers in concentrated salt solutions.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.jsb.2014.03.004
